Indications :
This combination medication contains semisynthetic antibiotic amoxicillin and β-lactamase inhibitor, prescribed for lower respiratory infections, otitis media, sinusitis, urinary tract infections, and skin and skin Structure infections.
Contraindications :
Contraindicated in patients with previous history of cholestatic jaundice/liver dysfunction, and hypersensitivity.
Dosage & When it is to be taken :
Adults - The usual adult dose is one amoxicillin and clavulanate potassium tablet, 500 mg/125 mg every 12 hours or one amoxicillin and clavulanate potassium tablet, 250 mg/125 mg every 8 hours.
Warnings & precautions :
Caution should be exercised in patients with history of liver or kidney disease, elderly, children, during pregnancy and breastfeeding. Avoid long-term use of this medication; otherwise it may cause secondary infection. It may increase prothrombin time; monitor it regularly while taking this medication.
Side Effects : Gastrointestinal -
Diarrhea, nausea, vomiting, indigestion, stomach inflammation, mouth ulcer and intestinal bleeding. Hypersensitivity -
Skin rashes, itching, hives, angioedema and serum sickness-like reactions. Liver -
Elevated liver enzyme levels. Genitourinary -
Kidney inflammation, and blood in urine. Central Nervous System -
Agitation, anxiety, behavioral changes, confusion, convulsion, dizziness, sleeplessness and reversible hyperactivity.